Example 1

Task: Humanize an antibody with an appropriate solved structure without the antigen

In this case, we have a pdb file called Ab1.pdb, in which there is the structure of the antibody of interest.

Query parameters:

Email address: youremail@academic_institute.edu

Submission name: Anything that you choose

Structure: Upload Ab1.pdb

Light Chain: L

Heavy Chain: H

Antigen Chain: None

Number of designs: 5

Example 2

Task: Humanize an antibody with an appropriate solved structure with the antigen

In this case, we have a pdb file called Ab2.pdb, in which there is the structure of the antibody of interest as well as the antigen. In this case, the identifier for the antigen is C.

Query parameters:

Email address: youremail@academic_institute.edu

Submission name: Anything that you choose

Structure: Upload Ab2.pdb

Light Chain: L

Heavy Chain: H

Antigen Chain: C

Number of designs: 5

Mode: CDR