CUMAb Frequently asked questions

**If you have specific questions that were not addressed in our about page, help boxes for each submission parameter or here, feel free to write us and we will add them.

Can I run CUMAb without a structure of the antibody?

No, CUMAb requires a structure of the antibody Fv. However, if you don’t have a structure, we recommend using the ABodyBuilder2 webserver (ABodyBuilder2) to generate a model for the antibody and then submit this to CUMAb.

How much time does a CUMAb calculation take?

The time required for CUMAb to complete a calculation depends on the number of other queries running in parallel. You may receive the output email within a few hours or within 1-2 days. If after 2 days you haven't received the output email, please contact us.

Can I submit a PSE file created by PyMOL?

No. You can't submit a PSE file.

Why do I get fewer designs than I asked for (or no designs at all)?

CUMAb outputs only humanized sequences that have a calculated energy up to a certain level above that of the inputted antibody. In some cases, CUMAb cannot find many (or any) sequences that meet these criteria. If this happens, please feel free to reach out to us and we will look in more detail at the specific case.